Zone-specific gene expression patterns in articular cartilage
نویسندگان
چکیده
منابع مشابه
Human articular cartilage zone specific gene expression profiling
Introduction: Human articular cartilage (HAC) possesses a unique structure and composition with variations in matrix biochemical composition, cell morphology, cell density, cell metabolism and pericellular matrix (PCM) in discretely organized zonal architectures. The superficial zone (SZ) spans the first 10-20% of full thickness HAC. The middle zone (MZ) is about 40-60% and the deep zone (DZ) t...
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Introduction The regeneration of articular cartilage remains a challenge and is an unmet clinical need in orthopaedic surgery. Since hyaline articular cartilage will not heal spontaneously, these lesions eventually lead to degenerative joint disease. Cartilage abrasion, subchondral drilling, and microfracture techniques stimulate articular cartilage healing by introducing endogenous “stem cells...
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BACKGROUND Articular cartilage undergoes an important maturation process from neonate to adult that is reflected by alterations in matrix protein organization and increased heterogeneity of chondrocyte morphology. In the horse, these changes are influenced by exercise during the first five months of postnatal life. Transcriptional profiling was used to evaluate changes in articular chondrocyte ...
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INTRODUCTION The molecular mechanisms underlying cartilage destruction in osteoarthritis are poorly understood. Proteolysis is a key feature in the turnover and degradation of cartilage extracellular matrix where the focus of research has been on the metzincin family of metalloproteinases. However, there is strong evidence to indicate important roles for other catalytic classes of proteases, wi...
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Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones. Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied. Methods: Using immunohistochemistry and standard we...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2013
ISSN: 0004-3591
DOI: 10.1002/art.37760